2019

Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant.  Nambiar, T.S., Billon, P., Diedenhofen, G., Hayward, S.B., Taglialatela, A., Cai, K., Huang, J.W., Leuzzi, G., Cuella-Martin, R., Palacios, A., Gupta, A., Egli, D., and Ciccia, A. (2019). Nature Comm. 10, 3395.

2018

The BRCT domains of the BRCA1 and BARD1 tumor suppressors differentially regulate homology-directed repair and stalled fork protection. Billing, D., Horiguchi, M., Wu-Baer, F., Taglialatela, A., Leuzzi, G., Alvarez, S., Jiang, W., Zha, S., Szabolcs, M., Lin, C.-S., Ciccia, A., and Baer, R.  (2018). Mol. Cell 72(1), 127-139.

2017

Restoration of replication fork stability in BRCA1- and BRCA2-deficient cells by inactivation of SNF2-family fork remodelers. Taglialatela, A., Alvarez, S., Leuzzi, G., Sannino, V., Ranjha, L., Huang, J.W., Madubata, C., Anand, R., Levy, B.,  Rabadan, R., Cejka, P., Costanzo, V., Ciccia, A.  (2017). Mol. Cell 68(2), 414-430.

CRISPR-mediated base editing enables efficient disruption of eukaryotic genes through induction of STOP codons. Billon, P., Bryant, E.E., Joseph, S.A., Nambiar, T.S., Hayward, S.B., Rothstein, R., Ciccia, A.  (2017). Mol. Cell 67(6), 1068-1079.

Replication fork slowing and reversal upon DNA damage require PCNA polyubiquitination and ZRANB3 DNA translocase activity. Vujanovic, M., Krietsch, J., Raso, M.C., Terraneo, N., Zellweger, R., Schmid, J.A., Taglialatela, A., Huang, J.W., Holland, C.L., Zwicky, K., Herrador, R., Jacobs, H., Cortez, D., Ciccia, A., Penengo, L., Lopes, M.  (2017). Mol. Cell 67(5), 882-890.

SMARCAL1-mediated fork reversal triggers MRE11-dependent degradation of nascent DNA in the absence of BRCA2 and stable RAD51 nucleofilaments. Kolinjivadi, A.M., Sannino, V., De Antoni, A., Zadorozhny, K., Kilkenny, M., Técher, H., Baldi, G., Shen, R., Ciccia, A., Pellegrini, L., Krejci, L., Costanzo, V. (2017). Mol. Cell 67(5), 867-881.

2014-16

Stressing out about RAD52. Ciccia, A.* and Symington, L.S.* (2016). Mol. Cell 64(6), 1017-1019.

* Corresponding authors

A systematic analysis of factors localized to damaged chromatin reveals PARP-dependent recruitment of transcription factors. Izhar, L., Adamson, B., Ciccia, A., Lewis, J., Pontano-Vaites, L., Leng, Y., Liang, A.C., Westbrook, T.F., Harper, J.W., and Elledge, S.J. (2015). Cell Reports 11(9), 1486-1500.

 

Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response. Ciccia, A.*, Huang, J.W., Izhar, L., Sowa, M.E., Harper, J.W., and Elledge, S.J.* (2014). Proc. Natl. Acad. Sci U S A 111, 18631-18636.

* Corresponding authors

2003-13

Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Zhu, J., Larman, H.B., Gao, G., Somwar, R., Zhang, Z., Laserson, U., Ciccia, A., Pavlova, N., Church, G., Zhang, W., Kesari, S., and Elledge, S.J. (2013). Nat. Biotechnol. 31(4), 331-334.

 

Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Ciccia, A., Nimonkar, A.V., Hu, Y., Hajdu, I., Achar, Y.J., Izhar, L., Petit, S.A., Adamson, B., Yoon, J.C., Kowalczykowski, S.C., Livingston, D.M., Haracska, L., and Elledge, S.J. (2012). Mol. Cell 47(3), 396-409.

 

Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage. Hajdu, I., Ciccia, A., Lewis, S.M., and Elledge, S.J. (2011). Proc. Natl. Acad. Sci. U S A 108(32), 13130-13134.

 

Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. Emanuele, M.J., Ciccia, A., Elia, A.E., and Elledge, S.J. (2011). Proc. Natl. Acad. Sci. U S A 108(24), 9845-9850.

 

Autoantigen discovery with a synthetic human peptidome. Larman, H.B., Zhao, Z., Laserson, U., Li, M.Z., Ciccia, A., Gakidis, M.A., Church, G.M., Kesari, S., Leproust, E.M., Solimini, N.L., Elledge, S.J. (2011). Nat. Biotechnol. 29(6), 535-541.

 

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Meerbrey, K.L., Hu, G., Kessler, J.D., Roarty, K., Li, M.Z., Fang, J.E., Herschkowitz, J.I., Burrows, A.E., Ciccia, A., Sun, T., Schmitt, E.M., Bernardi, R.J., Fu, X., Bland, C.S., Cooper, T.A., Schiff, R., Rosen, J.M., Westbrook, T.F., Elledge, S.J. (2011). Proc. Natl. Acad. Sci. U S A 108(9), 3665-3670.

 

A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. O'Connell, B.C., Adamson, B., Lydeard, J.R., Sowa, M.E., Ciccia, A., Bredemeyer, A.L., Schlabach, M. Gygi, S.P., Elledge, S.J., and Harper, J.W. (2010). Mol. Cell 40(4), 645-657.

 

The DNA damage response: making it safe to play with knives. Ciccia, A., and Elledge, S.J. (2010). Mol. Cell 40(2) 179-204.

 

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Ciccia, A., Bredemeyer, A.L., Sowa, M.E., Terret, M.E., Jallepalli, P.V., Harper,  J.W., and Elledge, S.J. (2009). Genes Dev. 23(20), 2415-2425. 

 

FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Collis, S.J, Ciccia, A., Deans, A.J., Horejsi, Z., Martin, J.S., Maslen, S.L., Skehel, J.M. Elledge S.J., West, S.C. and Boulton, S.J. (2008). Mol. Cell 32(3), 313- 324.

 

Structural and functional relationships of the XPF/MUS81 family of proteins. Ciccia, A., McDonald, N., and West, S.C. (2008). Annu. Rev. Biochem. 77, 259-287.

 

Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Ciccia, A., Ling, C., Coulthard, R., Yan, Z., Xue, Y., Meetei, A.R., Laghmani el, H., Joenje, H., McDonald, N., de Winter, J.P., Wang, W., and West, S.C. (2007). Mol. Cell 25(3), 331-343. 

 

EME1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. Abraham, J, Lemmers, B., Hande, M. P., Moynahan, M. E., Chahwan, C., Ciccia, A., Essers, J., Hanada, K., Chahwan, R., Khaw, A. K., McPherson, P., Shehabeldin, A., Laister, R., Arrowsmith, C., Kanaar, R., West, S.C., Jasin, M., Hakem, R.  (2003). EMBO J. 22, 6137-6147.

 

Identification and characterization of the human MUS81-EME1 endonuclease. Ciccia, A., Constantinou, A., and West, S. C (2003). J. Biol. Chem. 278(27), 25172-25178.